Received: OctoAccepted: ApPublished: May 5, 2022Ĭopyright: © 2022 Magaram et al. PLoS ONE 17(5):Įditor: Hongkyun Kim, Rosalind Franklin University of Medicine and Science Chicago Medical School, UNITED STATES Together, we demonstrate that multiple mechanosensitive proteins likely cooperate to transform ultrasound stimuli into behavioral changes.Ĭitation: Magaram U, Weiss C, Vasan A, Reddy KC, Friend J, Chalasani SH (2022) Two pathways are required for ultrasound-evoked behavioral changes in Caenorhabditis elegans. Finally, overexpressing TRP-4 in specific chemosensory neurons can rescue the ultrasound-triggered behavioral deficit in the mec-4 null mutant, suggesting that both TRP-4 and MEC-4 act together in affecting behavior. Further, the trp-4 mec-4 double mutant shows a stronger behavioral deficit compared to either single mutant. Next, we show that the pore-forming subunit of the mechanosensitive channel TRP-4, and a DEG/ENaC/ASIC ion channel MEC-4, are both required for this ultrasound-evoked reversal response. We first show that these animals generate reversals in response to a single 10 msec pulse from a 2.25 MHz ultrasound transducer. elegans behavioral responses to ultrasound stimuli. Here, we show that at least two mechanosensitive proteins act together to generate C. Ultrasound has been shown to affect the function of both neurons and non-neuronal cells, but, the underlying molecular machinery has been poorly understood.
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